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This Week in Cardiology

Feb 4, 2022

Interatrial shunt therapy, the power of the RCT, chronic stress, anxiety and cardiometabolic risk, and TAVR, are the topics covered by John Mandrola, MD, in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit:

I - Interatrial Shunt

- Interatrial Shunt Falters in Preserved, Mid-Range LVEF Heart Failure: REDUCE LAP-HF 2

- Atrial shunt device for heart failure with preserved and mildly reduced ejection fraction (REDUCE LAP-HF II): a randomised, multicentre, blinded, sham-controlled trial

II - Chronic Stress

- Chronic Stress Accelerates Aging: Epigenetic Evidence

- Psychological and biological resilience modulates the effects of stress on epigenetic aging

- DNA methylation GrimAge strongly predicts lifespan and healthspan

III – Anxiety, Neuroticism, and CardioMetabolic Risk Factors

- Anxiety in Men Tied to Risk Factors for CVD, Diabetes

- Neuroticism, Worry, and Cardiometabolic Risk Trajectories: Findings From a 40‐Year Study of Men

IV - TAVR Implant Success

- VARC-3 TAVR Technical Failure Definition 'Highly Clinically Relevant

- Validation of the Valve Academic Research Consortium 3 Technical Success Definition in Patients Undergoing TAVR

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