May 2, 2025
The FDA approval of TAVR for asymptomatic AS, digital health,
subcutaneous vs transvenous ICD, and cryptogenic stroke in young
adults are discussed by John Mandrola, MD.
This podcast is intended for healthcare professionals
only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I FDA announces approval for TAVR in pts with
asymptomatic AS
- Edwards Press Release
https://www.edwards.com/newsroom/news/2025-05-01-edwards-tavr-receives-fda-approval-for-patients-with-asymptomatic-severe-aortic-stenosis
- Transcatheter Aortic-Valve Replacement for Asymptomatic Severe
Aortic Stenosis (EARLY TAVR)
https://www.nejm.org/doi/full/10.1056/NEJMoa2405880
- EARLY TAVR: A Positive Trial That Fails to Inform Clinical
Decisions
https://www.medscape.com/viewarticle/early-tavr-positive-trial-fails-inform-clinical-decisions-2024a1000kec
- Asymptomatic Aortic Stenosis: 'Time to Act' or Not So Fast?
https://www.medscape.com/viewarticle/asymptomatic-aortic-stenosis-time-act-or-not-so-fast-2025a10005o9
II PPG that Can Distinguish source of
Tachycardia
- Machine-learning guided differentiation between
photoplethysmography waveforms of supraventricular and ventricular
origin https://doi.org/10.1016/j.cmpb.2025.108798
III PRAETORIAN -XL trial
- Device-related Complications in Transvenous Versus Subcutaneous
Defibrillator Therapy During Long-term Follow-up: the PRAETORIAN-XL
Trial
https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.074576
- Subcutaneous or Transvenous Defibrillator Therapy (PRAETORIAN
trial) https://www.nejm.org/doi/full/10.1056/NEJMoa1915932
- Subcutaneous or Transvenous Defibrillator Therapy Letter to
Editor https://www.nejm.org/doi/full/10.1056/NEJMc2034917
- The PRAETORIAN Trial: Guarded Approach to Subcutaneous ICD Best
https://www.medscape.com/viewarticle/937156
IV Stroke in Young People
- Burden of Modifiable Risk Factors in Young-Onset Cryptogenic
Ischemic Stroke by High-Risk Patent Foramen Ovale
https://www.ahajournals.org/doi/10.1161/STROKEAHA.124.049855
- Migraine: A Key Factor in Young Adults With Unexplained Stroke
https://www.medscape.com/viewarticle/migraine-key-factor-young-adults-unexplained-stroke-2025a10009jj
- U.S. stroke rate declining in adults 75 and older, yet rising
in adults 49 and younger ASA statement
https://newsroom.heart.org/news/u-s-stroke-rate-declining-in-adults-75-and-older-yet-rising-in-adults-49-and-younger
- Increasing stroke in the young
https://doi.org/10.1016/j.ajpc.2020.100085
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