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This Week in Cardiology


Feb 28, 2025

The treatment of asymptomatic aortic stenosis, the move to composite endpoints in trials, IFR vs FFR and high-frequency low tidal volume ventilation for AF ablation are the topics John Mandrola, MD, discusses in today's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I Aortic valve intervention for Asymptomatic AS

  • Lindman editorial https://jamanetwork.com/journals/jamacardiology/fullarticle/2829881
  • Trends https://pmc.ncbi.nlm.nih.gov/articles/PMC11308430/
  • Podcast EARLY TAVR Nov 8, 2024 This Week in Cardiology Podcast https://www.medscape.com/viewarticle/1001865
  • Faith Healing and Subtraction Anxiety https://www.ahajournals.org/doi/10.1161/circoutcomes.118.004665
  • Early TAVR trial https://www.nejm.org/doi/10.1056/NEJMoa2405880
  • EVOLVED https://jamanetwork.com/journals/jama/fullarticle/2825540
  • AVATAR https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.057639

II Trial Endpoints

  • Shepshelovich https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2830023
  • Brown meta-analysis https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2785560

III IFR vs FFR—a debate b/w RCTs and observational data

  • 5-year DEFINE https://jamanetwork.com/journals/jamacardiology/fullarticle/2824470
  • 5-year SwedeHeart IFR https://doi.org/10.1016/j.jacc.2021.12.030
  • Eftekhari meta-analysis https://doi.org/10.1093/eurheartj/ehad582
  • Gotberg SWEDEHEART Registry https://doi.org/10.1016/j.jcin.2024.12.003
  • Editorial of SWEDEHEART-Registry https://doi.org/10.1016/j.jcin.2024.12.014

IV High-frequency low-tidal-volume ventilation for AF ablation

  • Osorio et al https://doi.org/10.1016/j.hrthm.2024.07.094

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