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This Week in Cardiology

May 21, 2021

John Mandrola, MD, presents an ACC 2021 recap.

ACC 2021 Reveiw

I -- Left Atrial Appendage Closure

LAAOS III: Surgical LAA Closure Cuts AF Stroke Risk by One Third

- Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke

Watchman Registry: 1-Year Stroke Estimates Reassuringly Low

II - Angiotensin-Neprilysin Inhibition

PARADISE-MI: Sacubitril/Valsartan Can't Beat Ramipril in Patients With Acute MI

Life Trial

Rationale Paper:

III - Renal Denervation

Ultrasound Renal Denervation Drops BP in Patients on Triple Therapy

IV -- Clopidogrel vs ASA post Stent

HOST-EXAM: Clopidogrel Beats Aspirin as Monotherapy After Stenting

- Aspirin versus clopidogrel for chronic maintenance monotherapy after percutaneous coronary intervention (HOST-EXAM): an investigator-initiated, prospective, randomised, open-label, multicentre trial

V -- AF Ablation in HF

RAFT-AF, Despite Itself, Hints at Advantage for Ablation Rhythm Control in Heart Failure With AF.

VI -- Rivaroxaban in COVID-19 – ACTION Trial

Therapeutic Rivaroxaban Dose: Risk Outweighs Benefit in Stable COVID


Novel Rehab Program Fights Frailty, Boosts Capacity in Advanced HF

- Physical Rehabilitation for Older Patients Hospitalized for Heart Failure

VIII – ASA 81 vs 325 – ADAPTABLE Trial

ADAPTABLE: Low-Dose Aspirin as Good as High-Dose in CHD?

- Comparative Effectiveness of Aspirin Dosing in Cardiovascular Disease


Eight Things to Know About the Surgical Left Atrial Appendage Occlusion (LAAOS III) Trial

PARADISE-MI Makes Me Question the Benefits of Sacubitril/Valsartan

Sacubitril/Valsartan: Trending Toward PARADISE Post MI

Renal Denervation for Resistant Hypertension Is Not Back on Track

Acute Alcohol Consumption Raises Risk for Atrial Fibrillation

Does ADAPTABLE Inform Aspirin Dosing for Secondary Prevention?

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